Grant for Advancing Therapeutics in Neurodegenerative Diseases
GrantID: 74160
Grant Funding Amount Low: $500,000
Deadline: Ongoing
Grant Amount High: $5,000,000
Summary
This funding opportunity offers up to $5 million per award, structured as milestone-driven investments spanning multiple years. It supports advanced preclinical and early-phase clinical work aimed at developing new treatments for Alzheimer’s disease and related dementias. Focus areas include IND-enabling activities—such as toxicology, pharmacology, GMP manufacturing—and early human studies like Phase 0, Phase 1, and biomarker-driven proof-of-concept trials.
A broad array of therapeutic strategies is encouraged, including small molecules, antibodies, gene-based modalities, peptides, and even certain medical devices. Research targeting fundamental aging pathways—such as inflammation, neuroprotection, metabolic function, synaptic activity, proteostasis, epigenetics, mitochondrial or vascular mechanisms—is prioritized. However, interventions focused solely on diet, exercise, or meditation, and traditional anti-amyloid or cholinesterase-inhibitor approaches are not eligible.
Applicants can be based anywhere in the world, including academic medical centers, nonprofit institutions, and biotech companies—both startups and established firms—often in collaboration with industry partners. Eligible costs include direct research expenses such as personnel, consumables, manufacturing, and trial-related costs; indirect or overhead expenses are generally excluded.
Funding decisions hinge on rigorous scientific and commercial justification, with a strong emphasis on robust evidence of a novel mechanism, biomarker engagement, and viable recruitment strategies for clinical phases. Overall, this opportunity is intended for researchers or small biotech firms ready to accelerate promising therapeutic candidates toward clinical validation, with substantial investment to support impactful, translational progress in dementia treatment.
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